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Gefällt mir This video is not available.Resveratrol, a natural compound, exhibits potent antitumor effects in vitro and in vivo. Resveratrol (trans-3,5,4′-trihydroxystilbene) is a stilbene-like compound that is present in a number of plants, including grapes, peanuts, blueberries, raspberries, and mulberries. Resveratrol is a phytoalexin, which induces resistance to a range of pathogens in plants, and has many beneficial properties, such as anti-inflammatory and antioxidant effects. This study aimed to investigate the antitumor effects of resveratrol, as well as its cytotoxic mechanisms. Our results revealed that resveratrol inhibited cell viability and induced apoptosis, ROS production, DNA damage, and intracellular Ca(2+) release. In addition, resveratrol suppressed the migration and invasion of OVCAR-3 and SKOV-3 cells. Resveratrol-induced apoptosis in ovarian cancer cells was associated with up-regulation of the proapoptotic Bax protein and down-regulation of the antiapoptotic Bcl-2 protein. In addition, resveratrol up-regulated caspase-3 activity. Our findings suggested that resveratrol-induced apoptosis was mediated by an increase in ROS generation in the mitochondria of human ovarian cancer cells. In addition, inhibition of intracellular Ca(2+) has been shown to be closely associated with cell apoptosis. Our results demonstrate that resveratrol inhibited ovarian cancer cell proliferation and induced apoptosis by modulating the mitochondrial pathway. These findings indicate that resveratrol may be a potentially new anticancer agent for ovarian cancer therapy./249617 What is 1232326 (base 7) in base 5? 13340231 11ba2 (base 13) to base 16 7a5d Convert -141 (base 10) to base 3. -21010 Convert 1000100100100011 (base 2) to base 16. 5e07 Convert -11303000 (base 4) to base 15. -a8d0 Convert -8844 (base 10) to base 4. -1110310 -22434 (base 7) to base 14 -2292 Convert 1101032 (base 4) to

https://colab.research.google.com/drive/1uJDX6SyPODwCNIF8qjYBH_wAv0dDJwEj
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